New paper: Toward Noninvasive High-Resolution In Vivo pH Mapping in Brain Tumors by 31P-Informed deepCEST MRI
Congratulations to Dr. rer. nat. Jan-Rüdiger Schüre and co-authors on the recently published article “Toward Noninvasive High-Resolution In Vivo pH Mapping in Brain Tumors by 31P-Informed deepCEST MRI”!
This study used a neural network to predict intracellular pH (pHi) maps from high-resolution 1H-based APT-CEST and T1 data, aiming to replicate low-resolution 31P-MRS pHi measurements in brain tumor patients. The model showed good agreement with 31P-pHi (RMSE of 0.04 pH units in tumors) and revealed tumor heterogeneity not visible in conventional CEST, indicating it captures unique pH-related information. This method enables faster, higher-resolution pHi imaging, offering a promising clinical alternative to 31P-MRS.
The full article can be found here: